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3-(5-{[4-(aminomethyl)piperidin-1-yl]methyl}-1H-indol-2-yl)-1H-indazole-6-carbonitrile
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule with the IUPAC name "3-[5-[ [4-(aminomethyl)piperidin‑1‑yl]methyl ]‑1H‑indol‑2‑yl ]‑1H‑indazole‑6-carbonitrile". It has been identified as a potential inhibitor of Cancer Osaka Thyroid (COT) kinase, which is implicated in cancer cell proliferation and survival. In silico studies suggest it may act as a selective and potent anticancer agent by binding to the active site of COT kinase, potentially inhibiting its function. The compound has also been considered for other diseases such as cardiac hypertrophy and Alzheimer's disease in computational screening studies, but there are no reports of clinical development or approval. Its primary use remains experimental within medicinal chemistry research focused on kinase inhibition for oncology applications[6][5][3].
- Other names
- 3-(5-{[4-(Aminomethyl)piperidin-1-Yl]methyl}-1h-Indol-2-Yl)-1h-Indazole-6-carbonitrile3-(5-((4-(aminomethyl)piperidin-1-yl)methyl)-1H-indol-2-yl)-1H-indazole-6-carbonitrile
02
Targets
MAP3K8
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